036086 – Flow and Transport in Microdevices
Overview and objective
This course will provide a graduate-level introduction to fluid flow, mass transport, and physicochemical phenomena in microfluidic devices.
Microfluidics is a highly multidisciplinary field, which brings together physics, chemistry, electricity, fluid mechanics and engineering principles. Modern and relevant applications require combining knowledge from all of these fields to create new tools, new capabilities, and novel devices. To put it bluntly, in contrast to our undergraduate education, as mechanical engineers, we can no longer ignore the importance of molecules, and as chemical- or bio- engineers, we can no longer ignore the importance of mechanics. Thus, it is not a course in fluid mechanics, but rather on transport phenomena associated with fluid flow in microdevices.
While the principles we will study are generally applicable, we will emphasize bio-analytical applications, which remains a dominant driving force behind microfluidics. Topics include:
Brownian motion, scalar transport, Taylor-Aris dispersion, combined advection-diffusionreaction,
charged solutions, buffer systems, on-chip focusing and separation methods,
capillary flows, and droplet motion.
* Undergraduate level fluid mechanics (034013 or equivalent)
* Partial differential equations
What you should know
You should be comfortable with integral and differential formulations of conservation laws (mass, momentum, heat transfer) as well as classical thermodynamics, and have good control of mathematical tools such as vector algebra, calculus, and partial differential equations.
Grading will be based on homework (approx. 5-6 problem sets) and a final project due at the end of the semester.
There is no one specific textbook which covers all the material for this course. However any of the following books could be useful as reference:
1. Ronald F. Probstein, “Physicochemical Hydrodynamics”, Wiley 2003. (available as ebook from Technion)
2. L Gary Leal, “Laminar flow and convective transport processes – scaling principles and asymptotic analysis”, Butterworth-Heinemann, 1992
3. L. Gary Leal, “ Advanced transport phenomena, fluid mechanics and convective transport processes”, Cambridge University Press, 2007
4. Henrik Bruus, “Theoretical microfluidics”, Oxford University Press, 2008.
5. Brian J. Kirby, “Micro- and nanoscale fluid mechanics: transport in microfluidic devices”, Cambridge University Press, 2010. (available as ebook from Technion)
6. Howard C. Berg, “Random walks in biology”, Princeton University Press, 1993.